1 | Gaye et al.4 | Senegal | 2020 | 46 | 48 hours | White Blood Cell: 526000/mm3, Platelets: 412000/mm3, Myelogram result: bone marrow hyperplasia. Karyotyping: Translocation between chromosomes 9 and 22 | Imatinib (the dosage wasn’t mentioned) | Aspiration of corpora cavernosa, injection of phenylephrine, hydrocycarbamide | Success |
2020 | 9 | 36 hours | White Blood Cell: 82000/mm3, Platelets: 81000/mm3, BMA: acute myeloid leukemia | Vincristine and Prednisolone | penile skin refrigeration, rehydration, puncture of corpora cavernosa, injection of phenylephrine | Success |
2 | Rajabto et al.9 | Indonesia | 2020 | 44 | 4 days | physical exam: pale skin, conjunctival pallor, leukemic retinopathy in both eyes. Schuffer 2. | IV fluid, Allopurinol 300 mg, Sodium bicarbonate 500 mg 3 times daily, hydrocyurea 1 gram three, Imatinib 400 mg times a day | aspiration of penile corpus, injection of epinephrine | suffered ED |
Labs: anemia, hyperleukocytosis, microcytic hypochromic, anisopoikilocytosis, fragmentocytes, polychromic erythrocytes, a left shift, platelet count (355,000/μL), and hyperleukocytosis (399.560/μL). |
Positive BCR-ABL1 |
BMA: hypercellularity |
3 | Dhar et al.11 | India | 2019 | 52 | 4 hours | Physical examination: massive splenomegaly of 8 cm below the left costal margin along with hepatomegaly of 3 cm below right costal margin. | Hydroxyurea 500 mg TDS, Imatinib OD, Allupurinol 300 mg OD, adequate hydration | needle aspiration –> didn’t work, went for Winters procedure | Success |
Blood count: left sided granulopoeis, total leucocyte count of 239×109/L and platelet count of 625×109/L. |
BMA: findings of CML |
positive translocation of BCR-ABL |
4 | Becerra et al.12 | Mexico | 2018 | 52 | 6 day evolution | WBC: 282.000, platelets: 368×103/mm3 | dastinib 100 mg/day+G15 | corpora cavernosa irrigation and surgery penis shunts | Success |
BMA: acute phased CML |
translocation t (9:22)(q34;q11.2) with P210 BCR-ABL1 fusion transcriber |
5 | Khan et al.13 | Pakistan | 2018 | 16 | 264 hours | Leukocyte count: 614.8×109, platelets 709×1012/L, peripheral smear: myeloid hyperplasia, neutrophilia. BMA: myeloid hyperplasia. Detection of BCR-ABL | Hydroxyurea, allopurinol | Glans-cavernosal shunt | Achieved detumescence, No info on ED |
6 | Qu et al.14 | China | 2018 | 18 | 72 hours | Hepatosplenomegaly 2-3 cm under arcus costae, blood count: white blood cell (WBC) 257×109/L and platelets (PLT) 5450×109/L | Imatinib | Caverosa-corpus spongiosum shunt | No ED at 3 months follow up |
7 | Clark et al.15 | USA | 2018 | 13 | 3 days | Blood count: WBC count of 350,000/mL (350×109/L) and platelet count of 450×103/mL (450×109/L). Flow cytometry of blood: granulocytosis with no increase in blasts | leukapharesis, IV fluids, hydroxyurea, allupurinol, Imatinib | phenylephrine injection, three times corporeal irrigation | improved with phallus rigidity and tenderness |
BMA: Philadephia chromosome |
8 | Kumar et al.16 | India | 2018 | 47 | 5 days | Hepatosplenomegaly, WBC: 279×109, 91.2%BCR | Hydroxyurea, Imatinib | Aspiration and irrigation with phenlyephrine, Winter’s T Shunt | Successful treatment |
42 | 7 days | Splenomegaly 6 cm below costal margin, WBC: 390×109/L, 70,7% BCR-ABL ratio | Hydroxyurea, Imatinib | Aspiration and irrigation | Successful treatment |
28 | 6 days | No hepatosplenomegaly, WBC: 206×109/L, 75.3% BCR-ABL ratio | Hydroxyurea, Imatinib | Aspiration and irrigation with phenlyephrine, Winter’s T Shunt | Successful treatment |
9 | Sun et al.5 | USA | 2018 | 27 | 8 years, persistent erection 9 hours | Labs: anemia, WBC 450,010, Platelets 509,000/mm3 BMA: 2% blasts, hypercellular bone marrow, granulocytic hyperplasia, small megakaryocytes. BCR-ABL did not reveal clonal evolution. | Leukapheresis, hydoxyurea 500 mg daily, allopurinol 300 mg daily, Imatinib 400 mg daily, | Corporal bpody aspiration, 1 dose of phenylephrine injection | Successful treatment |
10 | Huei et al.17 | Malaysia | 2018 | 28 | 48 hours | hepatomegaly 2cm below right costal margin, splenomegaly, anemia, WBC 294×109, platelets: 94×109/L Peripheral blooad smear: hyperleucocytosis, blast cells | Hydroxyurea, allupurinol, intravenous Cytarabine | Intracavernosal aspiration, phenylephrine irrigation–> detumescent –> reccurent erection –> corpoglandular shunt | Successful treatment |
11 | Minckler et al.6 | USA | 2017 | 18 | 3 month intermittent | WBC: 588×103/uL, platelets: 109×103/uL | Hydroxyurea transtition to imatinib 400 mg daily | Penile irigation and aspiration | Success |
peripheral blood: hyperleukocytosis with absolute neutrophilia and a peripheral blast count of 2%. |
bone marrow aspirate and biopsy: hypercellular marrow with 4% blasts |
FISH analysis: translocation t(9:22) |
12 | Nerli RB et al.7 | India | 2016 | 19 | duration: 24 hours | WBC 296800, platelet 936,000/mm3, BMA: hypercellular, increased megakaryocytes | Hydroxyurea 1.5 gram daily, Imatinib 40 mg daily Allupurinol 300mg daily per oral | Irrigation, decompression | Successful |
13 | Ergenc H et al.18 | Turkey | 2015 | 18 | duration: 72 hours | Hepatosplenomegaly 2-3 cm under arcus costae, anemia, WBC 100.000, platelets 1,002,000/mm, peripheral blood smear: immature leukocytes. BMA: hypercellularity with myeloid hyperplasia, positive BCR-ABL translocation | Imanitib 400 mg once daily, allopurinol 300 mg once daily, leukapharesis | not mentioned | Success |
14 | Shaeer et al.2 | Egypt | 2015 | 21 | 6 days | palpable splenomegaly, WBC 410000, Philadelphia chromosome translocation | Leukapharesis, Imatinib 400 mg daily | failed several cavernosal aspiration and injection of epinephrine –> penile prosthesis | No complication throughout 6 months-follow up |
15 | Osorio et al.19 | Spain | 2014 | 24 | 14 hours, the second episode. The first episode was 4 months ago | WBC: 177.15×109, platelet was not mentioned, cytogenic diagnosis: showing CML | Imatinib | Corpora cavernosa aspiration, intracavernosa fenilefrin injection | not mentioned |
29 | 6 hours, the second episode. The first episode was less than a month ago | WBC: 402.24×109, platelet was not mentioned positive BCR-ABL | hyrdoxyurea | Corpora cavernosa aspiration, intracavernosa fenilefrin injection | not mentioned |
16 | Hazra et al.20 | India | 2013 | 14 | 24 hours | Splenomegaly 6 cm below the left costal margin, anemia, WBC 226900, platelets 310,000/uL, Peripheral blood smear: immature leukocytes in various stages. BMA: CML. | Hydroxyurea 50 mg/kgBB/day, Allupurinol 300 mg/day | Cavernosal aspiration and phenylephrine irrigation | No recurrence at 2-months-follow-up |
17 | Veljkovic et al.21 | Serbia | 2012 | 16 | 24 hours | Splenomegaly 4 cm below costal margin, WBC 320×109/L, Platelet (Plt) 417×109/L BMA: extreme hypercellularity, BCR/ABL positive | leukapharesis, cytoreductive chemotherapy | leukapharesis | no follow up |
18 | Paladino et al.3 | Spain | 2011 | 16 | 48 hours | Splenomegaly, WBC 312.000, PLT: 60.000/mm3 BMA: showing CML | no mention | Corpora cavernosa drainage | Erectile dysfunction |
19 | Gupta et al.22 | India | 2009 | 12 | 48 hours | Hepatosplenomegaly below the costal margins, anemia, WBC: 346×109/L, platelet count of 40,000/mm3, peripheral blood smear: immature myeloid leukocytosis. Cytogenesis: philadelphia chromosome. BCR-ABL transcript was positive | hydroxyurea 4g/day IV fluid 3L/day, allopurinol, Imatinib 400mg/day, leukapharesis | Terbutaline 0.125 mg subcutaneously | Resolved by 24 h |
20 | Ilais Tazi23 | Morocco | 2009 | 33 | duration: 22 hours | Palpable splenomegaly 4 cm below left costal margin, WBC: 400000/mm3, platelets 1200000/mm3. Peripheral blood smear: immature leukocytes. Karyotyple analysis: Ph1 chromosome, myeloid hyperplasian in the bone marrow. | Imatinib | Aspiration | Success |
21 | Castagnetti et al.24 | Netherland | 2008 | 9 | several days | splenomegaly, anemia, WBC: 509×109/L, philadelphia chromosome, BCR-ABL + | Hydroxyurea 1.5mg/m2/day, Cyclophosphamide 250 mg/m2/day for 2 days, leukopharesis | cytoreduction, antibiotics, anticoagulants | Fully resolved after 1 month |
9 | 96 hours | mild splenomegaly | Hydroxyurea 1g/m2/day | LMWH 90 units/kg SQ BID for 1 month, metamizole | fully resolved after 3 months |
9 | 9 hours | hepatosplenomegaly | Cyclophosphamide 250 mg/m2/day for 2 days, leukapharesis | LMWH 90 units/kgBB SQ BID for 9 days, metamizole, morphine | fully resolved after 20 days |
22 | Yoshida et al.25 | Japan | 2007 | 29 | 48 hours | WBC 263000 | Imatinib mesylate | Winter procedure | no evidence of recurrent |
23 | Lopez et al.26 | Spain | 2004 | 29 | 10 hours | WBC 414×109/L, BMA: hypercellularity, PLT: 1100 × 109/L | corpora cavernosa aspiration, phenylephrine injection | corpus cavernosum aspiration, fenilefrin injection | Successful treatment |
24 | Ponniah et al.27 | United Kingdom | 2004 | 19 | 18 hours | WBC 513×109/L | Leukapharesis | failed cavernosal aspiration + leukapharesis | No ED on follow up |
25 | Dogra et al.28 | India | 2003 | 18 | 10 days | hepatosplenomegaly, anaemic, WBC 320000, PLT was not mentioned | Intravenous hydration, furosemide, sodium bicarbonate, hydroxyurea, allopurinol, leukapharesis | Winters Procedure | impotent and enlarged penis at 3-months follow up |
26 | Meng-Wei Chang et al.8 | Taipei | 2003 | 21 | 19 hours | Hepatomegaly 6 cm below right arcus costae, Splenomegaly 7 cm below left arcus costae, anemia, WBC 216800, Platelet 1746,000/mm3 | Interferon alfa-2a (6MIU/vial), allopurinol 300 mg daily | Aspiration, epinephrine irigation | Success |
27 | Guerra et al.29 | Spain | 2002 | 53 | 12 hours | WbC 968×109/L | Hydroxyurea | Corpora cavernosa aspiration | Successful treatment |
28 | Murayama et al.30 | Japan | 2001 | 14 | 4 days | WBC 510000, BMA: myeloid hyperplasia, karyotype analysis: chromosome Ph1 | urokinase, hydroxyurea | embolization of bilateral pudendal artery | Reduced sexual potency |
29 | Rojas et al.31 | Chilli | 1998 | 22 | duration: 36 hours | none | Leukapharesis | Surgical intervention | Unsuccessful (post treatment sexual dysfunction) |